The concept of Integrated Medicine (IM) has been clearly defined for the first time in Italy on 3rd December 2011, when SIOMI presented its manifesto for IM, containing the conceptual and functional definitions of this discipline as agreed with the Italian leading health institution. The event has been celebrated with a monographic edition of HIMed (Homeopathy and Integrated Medicine, SIOMI’s official journal)1 in which the individual assertions written in the manifesto have been accompanied by the thorough scientific, clinical, ethical, and epistemological analysis habitually required to allow a complex discipline to interact transparently and safely with patients, doctors, and the medical world.