Herpes Zoster (HZ) is a viral disease resulting from the reactivationof Vericella Zoster virus (VZV) which remains latent in the nerveganglion after primary infection. The commonest complication ofHZ is Post herpetic neuralgia (PHN). When the body immunity goesdown then the latent VZV become active in the sensory gangliaand causes inflammatory neural damage which subsequently leadsto the incidence of PHN and acute neuralgic pain. Both the centraland peripheral nervous system are affected. But the intensity ofsuffering of this disease is less in children than in adults. Incidence ofPHN is common in elderly persons and is a serious problem to themwith sleepless nights (insomnia) that may persists several years. There isno definite consensus on the definition of PHN but in the latest studiesit is defined as pain persisting more than 3 months after the rash hashealed.In this study we treated 100 HZ cases of different age and sex; withhomeopathic medicines (Rhus tox & Thuja oc.) but no one developedPHN after one to six months of follow up and in all patients rashes orlesions were healed within 8-12 days, which may indicate the positiverole of these medicines to prevent PHN. The results of this study werevery encouraging indicating a definite role of homoeopathic medicinein HZ and PHN.