The first report of classical homeopathy is relatively recent, dating to 1997 when Friese and colleagues1–3 reported on an open study comparing the results obtained treating otitis media in children. The children were treated using two different medical approaches. The researchers compared classical unitary homeopathic remedies (Aconitum, Apis mel., Belladonna, Lachesis, Pulsatilla, Silicea, Lycopodium, Chamomilla, and Capsicum) prescribed after an individual homeopathic case analysis, with conventional therapy based on antibiotics, mucolytics, and antipyretics. Subjects in a homeopathic group experienced pain for 2 days and subjects in a conventional therapy group experienced 3 days of pain, and the duration of therapy was 4 and 10 days, respectively. The latter difference was statistically significant, but it should be noted that the duration of antibiotic therapy for these conditions cannot be shorter than a week, so this comparison may not reflect the clinical outcomes. In brief, this pragmatic study comparing homeopathic with conventional therapy showed that results were similar, but with a trend in favor of homeopathy.