Despite the marvelous advancements in modern biotechnology and medical practices, the use of complementary and alternative medicine (CAM) is rapidly evolving and growing in the healthcare industry and has significantly increased in all modern societies. The health-seeking behavior of people, especially in developing countries, calls for bringing all CAM healers into the mainstream by providing them with proper training, facilities, and backup for a referral. Evidence-based CAM (EBCAM) therapies have shown remarkable success in treating diseases. It necessitates the integration of modern CAM systems in terms of evidence-based information sharing. Although a synergistic effect of interaction between the two systems works, large gaps in EBCAM still exist and are worth further studies to develop evidence for best CAM practices for the common goal of improving the health of people.