Pro-inflammatory cytokines and their chronic effect – low-grade inflammation – have been associated with diverse chronic conditions. Nonsteroidal anti-inflammatory drugs (NSAIDs) were recently proposed as a treatment strategy. Samuel Hahnemann, the founder of homeopathy, had already hypothesized a systemic and progressive disorder as the cause of many chronic diseases – the Psora theory. He also advised of the consequences of palliative use for chronic diseases, as a contrary effect of the “of the life-preserving principleâ€? could worsen the course of those diseases. The hypotheses presented here are that the main aspects of Hahnemann’s Psora theory are supported by current data on the role of pro-inflammatory cytokines and that the use of NSAIDs to treat chronic low-grade inflammation can produce a contrary, rebound effect, as anticipated by Hahnemann. By diverting from the “palliative action-rebound effectâ€? course, not only homeopathy but integrative medicine could provide different approaches to the treatment of low-grade chronic inflammation. Studies assessing inflammatory markers in chronic integrative treatments are recommended.